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New twin-column chromatography system specifications and application information. The Contichrom TWIN LPLC is a multi-column system that performs continuous batch, sequential chromatography and batch chromatography with additional option for buffer in-line dilution.
Technology and Economics for the Purification of Oligonucleotides (and Peptides) by Twin-Column Continuous Chromatography
Conventional HPLC approaches force you to choose: You can increase your yield or improve purity in your peptide / oligo / ADC / RNA purification step.
However, that doesn’t have to be the case. Watch our webinar, hosted by Thomas Müller-Späth, COO of YMC ChromaCon, to learn how our Contichrom platform allows you to triple your yield while maintaining target purity and reducing solvent buffers by up to 70%.
Integrating a stainless steel based multi-column platform into a GMP single-use (SU) manufacturing suite successfully at clinical scale has been enabled on several YMC systems by a proprietary SU to durable interface.
Continuous capture chromatography as part of an integrated downstream purification platform for mAbs
Four unit operations engineered into a multi-column platform with an option for single-use technology for buffers at production scale can help achieve an early ROI and enhance productivity.
White paper examines considerations when evaluating buffer in-line dilution and how to set up program on EcoPrime LPLC / BID platform.
Multi-column capture processes show several advantages compared to batch capture. It is however not evident how many columns one should use exactly. Researchers at ETH / Zurich investigated this issue. Their findings are summarized in a free poster
NEW POSTER: Multi-column capture processes show several advantages compared to batch chromatography. Recent work on GMP scale 2-column system provides insight on design features, performance and a scale up tool. The work done at the Fraunhofer Institute is summarized in a free poster.
Short video on this system is found here.