The same buffer every time

Downstream processing of monoclonal antibodies and other recombinant proteins requires large volumes of buffer to maintain pH and conductivity during chromatographic purification steps and to stabilize proteins during hold steps and processing. YMC Process Technologies’ Buffer In-line Dilution (BID) systems with digitally-controlled, diaphragm metering pumps and optimized fluidic design deliver precise and accurate flow of both buffer concentrate and diluent assuring better control of final buffer composition and minimizing variation of critical quality attributes (ionic strength, concentration, pH, and conductivity).

Standard, pre-engineered or custom-designed systems with Merck-MilliporeSigma as our partner

With a deep understanding of system requirements for fluid blending and your buffer composition and capacity requirements—MilliporeSigma can provide a YMC manufactured standardized platform stand alone BDS systems with concentrates and single use components (bags, tube sets...) and YMC can handle customized solutions or BID built into our standard chromatography systems to help you:

  • Produce consistent point-of-use buffers
  • Automate complex dilution processes
  • Minimize operator exposure to potential chemical hazards
  • Reduce labor costs associated with buffer preparation
  • Reduce the footprint of your tank farm by using smaller tanks
  • Reduce CIP volume and waste
  • Increase scheduling flexibility by enabling the use of buffer concentrates in convenient single-use bags

Please ask us to share specific examples of the reliability and efficiency gains we've helped our customers achieve with our buffer in-line dilution (BID) systems.

The exclusive design delivers unrivaled performance

The system includes our proprietary digital control, pump technology, optimized system design, and sensors to monitor the dilution process. System software and automation allows the user to configure and run recipes that accurately and precisely blend the constituent solutions to produce ready-to-use buffers.

  • Automatically prepares accurate and precise buffers at point-of-use or a central location.
  • Enables dilution factors of up to 50:1 with ≤ ±1% variation in flow accuracy and precision.
  • Robust and simple buffer dilution based on control with volumetric flow rate to ensure consistent buffer ion composition.
  • Fluidic design that facilitates mixing, reduces time required to reach set points, and enables drainability.
  • User adaptable software that is recipe-driven with configurable, pre-programmed sequences that minimizes operator intervention.

The exclusive design delivers unrivaled performance

  • Buffer In-Line-Dilution for downstream processes- central systems or built into your chromatography skid
  • Liquid-to-Liquid precision blending
  • Point-of-use dilution from of concentrates
  • In-line dilution as an integral feature of GMP EcoPrime LPLC systems