Downstream processing of monoclonal antibodies and other recombinant proteins requires large volumes of buffer to maintain pH and conductivity during chromatographic purification steps and to stabilize proteins during hold steps and processing. YMC’s Buffer In-line Dilution (BID) systems with digitally controlled, diaphragm metering pumps and optimized fluidic design deliver a precise and accurate flow of both buffer concentrate and diluent. This ensures better control of final buffer composition and minimizes the variation of critical quality attributes, such as (ionic strength, concentration, pH, and conductivity).
YMC can provide a standardized platform BID system, a customized system, or a BID functionality built into our standard chromatography system to help you:
Please ask us to share specific examples of the reliability and efficiency gains we’ve helped our customers achieve with our BID systems.
The BID system includes our proprietary digital control, pump technology, optimized system design, and sensors to monitor the dilution process. System software and automation allow the user to configure and run recipes that accurately and precisely blend the constituent solutions to produce ready-to-use buffers. Our BID system:
BID for downstream processes using central systems or built into your chromatography skid:
Enhanced Buffer In-Line Dilution White Paper
YMC EcoPrime® Buffer In-Line Dilution (EcoPrime BID)
YMC EcoPrime Twin LPLC Platform – FAQ’s
YMC BID Capabilities
Integrated Buffer Delivery and Management Utilizing Buffer Concentrates and an Automated Dilution System
YMC EcoPrime Caustic Dilution Systems
YMC Insight Center – A Virtual Tour
Standard or Custom Downstream Processes
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